A Crack in Creation

A trailblazing biologist grapples with her role in the biggest scientific discovery of our era a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene editing tool CRISPR a revolutionary new technology that she helped create to make heritable changes in human embryos The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world s hunger crisis Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create better humans Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life With CRISPR, she shows, we have effectively taken control of evolution What will we do with this unfathomable power Best Download [ A Crack in Creation ] by [ Jennifer A. Doudna ] – kino-fada.fr This book s coauthor, Jennifer Doudna, together with Emmanuelle Charpentier published a seminal 2012 paper that demonstrated that CRISPR Clustered Regularly Interspaced Short Palindromic Repeats could be used for programmable gene editing The whole field of CRISPR has since become the hottest focus of biological research because its use now provides a relatively low cost and simple way to make precise changes to the double helix DNA strand.This book is written in the first person voice of Dou This book s coauthor, Jennifer Doudna, together with Emmanuelle Charpentier published a seminal 2012 paper that demonstrated that CRISPR Clustered Regularly Interspaced Short Palindromic Repeats could be used for programmable gene editing The whole field of CRISPR has since become the hottest focus of biological research because its use now provides a relatively low cost and simple way to make precise changes to the double helix DNA strand.This book is written in the first person voice of Doudna and first tells of her academic training and how she came to learn about CRSPR Then the book provides a short history of the development of gene splicing techniques Various methods of gene targeting and splicing had been developed TALEN and ZFNs prior to the discovery of CRISPR, but they were difficult and expensive procedures The ...A great explanation of CRISPR Cas9 that recounts the research that uncovered it and makes a case for determining how we will responsibly control and wield this powerful tool in future gene editing The ethical and moral questions are very difficult, and Doudna Sternberg don t pretend to have solid answers, and instead encouragediscussion and, above all, communication because governments and society as a whole will have to drive pol...Last time a book gave me this feeling of awe and amazement was reading Stephen Hawkin s Brief history of time 20 years ago It speaks volumes to Jennifer s ability to distilled the essential on this complex topic that I left feeling I had a good grasp on the subject albe...I won this book in a Goodreads giveaway Definitely a subject I d be interested in but maybe I wouldn t have pursued it otherwise, so thanks Goodreads.Me being me, I found myself turned off by the personal element of the book It s a good writing technique it personalizes all the scientific information, which could be otherwise dry or hard to follow for some readers, and lends a natural timeline around which to structure the unfolding of the tale of CRISPR So, objectively, very well done Sub I won this book in a Goodreads giveaway Definitely a subject I d be interested in but maybe I wouldn t have pursued it otherwise, so thanks Goodreads.Me being me, I found myself turned off by the personal element of the book It s a good writing technique it personalizes all the scientific information, which could be otherwise dry or hard to follow for some readers, and lends a natural timeline around which to structure the unfolding of the tale of CRISPR So, objectively, very well done Subjectively, I don t particularly want to hear about the story of anyone s life as it r...A CRACK IN CREATION Gene Editing and the Unthinkable Power to Control Evolution 2017 Doudna SternbergThis work is a short history of CRISPR, a term that refers to a region of bacterial DNA The acronym stands for clustered regularly interspaced short palindromic repeats The author attempts to show what these repeats are by the use of simple drawings and a further definition of the use of the term palindrome Although I had worked in AgBiotech towards the end of my career, th A CRACK IN CREATION Gene Editing and the Unthinkable Power to Control Evolution 2017 Doudna SternbergThis work is a short history of CRISPR, a term that refers to a region of bacterial DNA The acronym stands for clustered regularly interspaced short palindromic repeats The author attempts to show what these repeats are by the use of simple drawings and a further definition of the use of the term palindrome Although I had worked in AgBiotech towards the end of my career, the term was new to me I left the field in 200...Pretty dry and hyper technical or at least poorly explained re the details surrounding the CRISPR discovery and how CRISPR works I learned much, muchfrom Siddhartha Mukherjee s The Gene re genetics in general and what all this DNA RNA stuff does which then makes understanding CRISPR relatively straightforward The rest of this book, concerning all the ways CRISPR is or will be being used, was muchinteresting and worth reading.If you re interested in CRISPR but don t want t Pretty dry and hyper technical or at least poorly explained re the details surrounding the CRISPR discovery and...was the ground breaking paper not sure if I should post the link to the full article here published by the authors of this book along with other researchers that made way for a technology that has alarmed scientists with its potential to the extent that comparisons with nuclear fission are ubiquitous Being in an unrelated field of Engineering, the scientific article was difficult to fully comprehend over the years since it was published, but having was the ground breaking paper not sure if I should post the link to the full article here published by the authors of this book along with other researchers that made way for a technology that has alarmed scientists with its potential to the ext...I want to say this book is a must read It is really, really good The scientific explanations are concise and distill what I m sure are really complex processes into something digestible and does a much better job of this than Siddhartha Mukherjee s book, in my opinion The technology of gene editing is going to have some serious ramifications in perhaps the near future Jennifer Doudna gives a future with gene editing a thoughtful treatment and encourages us all to understand a...This is simply amazing research and I am in awe of Doudna The book is really sciency, which is good, but I was less interested in the play by play than in the possibilities no, I am not a scientist Nevertheless, a great read.From studying how bacteria fight off viral infections to development of the Life not personal but humanity changing technologies of CRISPR Cas9 This book a great, mostly understandable primer on the development and technologies used Understandable even for a 61 year old who has no microbiology background at all My experience of this book comes in 3 parts.1 In the first part, I learned some about microbiology Exciting to see advances, I found myself caught up in the excitement Who knew th From studying how bacteria fight off viral infections to development of the Life not personal but humanity changing technologies of C...

• English
• 14 June 2018
Jennifer A. Doudna
• Hardcover
• 304 pages
• 0544716949
• Jennifer A. Doudna
• A Crack in Creation